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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LMNA All Species: 14.85
Human Site: S599 Identified Species: 29.7
UniProt: P02545 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P02545 NP_005563.1 664 74139 S599 G Q P A D K A S A S G S G A Q
Chimpanzee Pan troglodytes NP_001092024 664 74135 S599 G Q P A D K A S A S G S G A Q
Rhesus Macaque Macaca mulatta XP_001113604 726 80498 S661 G Q P A D K A S A S G S G A Q
Dog Lupus familis XP_864434 665 74207 S600 G Q P A D K A S A S S S G A Q
Cat Felis silvestris
Mouse Mus musculus P48678 665 74219 A600 C G Q P A D K A A G G A G A Q
Rat Rattus norvegicus P48679 665 74305 A600 C G Q P A D K A A S G S G A Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516432 873 92759 V682 G E G A G A G V S A S R L P Q
Chicken Gallus gallus P13648 657 73146 L590 N L R S R T V L C G T C G Q P
Frog Xenopus laevis P11048 665 74901 V600 G R P A E K S V L A S Q G S G
Zebra Danio Brachydanio rerio NP_694503 659 73714 V592 Y N L R S R T V L C G S C G Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P08928 622 71282 N558 Q K W V S A D N T R T I L L N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q21443 566 64066 T502 L A P H A S A T V W S A D A G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 90.5 98 N.A. 96.5 97.1 N.A. 47.4 78.6 73.3 66.7 N.A. 35 N.A. 27.5 N.A.
Protein Similarity: 100 99.8 90.9 99.2 N.A. 98.9 98.9 N.A. 54.9 86.7 86.1 81.6 N.A. 57.9 N.A. 43.8 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 33.3 46.6 N.A. 20 6.6 33.3 20 N.A. 0 N.A. 20 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 46.6 53.3 N.A. 40 13.3 66.6 26.6 N.A. 13.3 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 50 25 17 42 17 50 17 0 17 0 59 0 % A
% Cys: 17 0 0 0 0 0 0 0 9 9 0 9 9 0 0 % C
% Asp: 0 0 0 0 34 17 9 0 0 0 0 0 9 0 0 % D
% Glu: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 50 17 9 0 9 0 9 0 0 17 50 0 67 9 17 % G
% His: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 0 9 0 0 0 42 17 0 0 0 0 0 0 0 0 % K
% Leu: 9 9 9 0 0 0 0 9 17 0 0 0 17 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 9 0 0 0 0 0 9 0 0 0 0 0 0 9 % N
% Pro: 0 0 50 17 0 0 0 0 0 0 0 0 0 9 9 % P
% Gln: 9 34 17 0 0 0 0 0 0 0 0 9 0 9 67 % Q
% Arg: 0 9 9 9 9 9 0 0 0 9 0 9 0 0 0 % R
% Ser: 0 0 0 9 17 9 9 34 9 42 34 50 0 9 0 % S
% Thr: 0 0 0 0 0 9 9 9 9 0 17 0 0 0 0 % T
% Val: 0 0 0 9 0 0 9 25 9 0 0 0 0 0 0 % V
% Trp: 0 0 9 0 0 0 0 0 0 9 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _